Clinicopatological Examination of Waldeyer’s Ring Lymphomas: A Cross-Sectional Study in Turkey

Authors : Çiğdem ÖZDEMİR, Nilhan ERYEĞEN, Filiz YAVAŞOĞLU, Mehmet Olgun AK, Selçuk KUZU, Mustafa DURAN, Burcu BELEN AYDOĞMUŞ, Büşra ÇETİNKAYA, Abdulkadir BUCAK, Yiğit ŞENOL

Pages : 81-88

Doi:10.53424/balikesirsbd.1241429

View : 14 | Download : 11

Publication Date : 2023-03-15

Article Type : Research Paper

Abstract :Objective: Waldeyer\`s ring insert ignore into journalissuearticles values(WR); is the second most common site of extranodal lymphomas. Its clinical course may resemble those of nodal lymphomas. We evaluated the histopathological and clinical findings, Epstein-Barr virus insert ignore into journalissuearticles values(EBV); presence, and overall survival of WR lymphomas diagnosed in our department. Materials and Methods: Retrospectively, 32 patients were included. The demographic and clinical data of the patients and lymphoma types, the presence of EBV [EBV early RNAs insert ignore into journalissuearticles values(EBER);] by chromogenic in-situ hybridization insert ignore into journalissuearticles values(CISH); method were examined. Kaplan-Meier analysis was used for the survival rate. A P value less than 0.05 was considered statistically significant. Results: 23 of 32 cases were male. The mean age was 57.97±16.15 years. The preliminary clinical diagnosis was carcinoma in 46.9% of the cases. Tonsil and nasopharynx had equal proportions as lymphoma origin. Only 3 insert ignore into journalissuearticles values(9.4%); cases are classic Hodgkin lymphoma insert ignore into journalissuearticles values(CHL);. 16 cases insert ignore into journalissuearticles values(50.0%); were diffuse large B-cell lymphoma insert ignore into journalissuearticles values(DLBCL);. EBER was detected only in tonsillar CHL cases. The survival of patients with nasopharyngeal lymphoma was shorter than those of tonsillar origin insert ignore into journalissuearticles values(p=0.037);. Conclusion: DLBCL is the most common lymphoma type of this localization. EBER positivity has been detected only in CHL. Survival is lower in lymphomas originating from the nasopharynx
Keywords : Non Hodgkin Lenfoma, Waldeyer Halkası, Nazofarenks, Tonsil, EBER