The Preparation of Liposomal Formulations of Gentamicin and Ceftiofur Used in Veterinary Medicine

Authors : Hasan SUSAR, Murat ÇELEBİ, Çağla ÇELEBİ, Özlem ÇOBAN, Hüseyin ŞEN, İzzet KARAHAN

Pages : 554-559

Doi:10.53424/balikesirsbd.1262051

View : 54 | Download : 50

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Objective: The aim of this study is to produce liposomal drugs that are scarcely found in veterinary medicine. Therefore, the current study was designed to produce liposomal formulations of ceftiofur and gentamicin for veterinary use and to perform their quality control studies. Materials and Methods: The Bangham Method was chosen for the preparation of liposomal formulations of gentamicin and ceftiofur. Results: The particle size, polydispersity index and zeta potential were found to be 3934.67 nm, 0.471, -10.3 mV for Ceftiofur-1 coded formulation, 4573.0 nm, 0.308, -9.9 mV for Ceftiofur-2 coded formulation, 479.4 nm, 0.437, -44.8 mV for Ceftiofur-3 coded formulation, respectively. The particle size, polydispersity index and zeta potential were found to be 5185.67 nm, 0.599, -6.5 mV for Gentamicin-1 coded formulation, 4228.0 nm, 0.505, -7.8 mV for Gentamicin-2 coded formulation, 2138.67 nm, 0.565, -6.5 mV for Gentamicin-3 coded formulation, respectively. The encapsulation efficiency of liposomal formulations containing ceftiofur; 82.85%, 95.74%, and 92.06% was found for ceftiofur-1, ceftiofur-2 and ceftiofur 3, respectively. Conclusion: The liposomal formulations of ceftiofur and gentamicin were successfully prepared and their quality control studies were carried out. It was concluded that pharmacokinetic/pharmacodynamic studies should be performed to evaluate the efficacy of liposomal formulations.
Keywords : Drug, Formulation, Liposome, Veterinary