Influence of Heat Shock Protein (HSP-70) Enhancing Compound From Red Alga (Porphyridium cruentum) for Augmenting Egg Production in Copepod Culture – A New In Silico Report

Authors : Kareem ALTAFF, Radha VIJAYARAJ

Pages : 186-192

Doi:10.33714/masteb.843705

View : 8 | Download : 6

Publication Date : 2021-06-05

Article Type : Other Papers

Abstract :The present study reports in silico investigation of bioactive compounds from marine microalgae capable of escalating copepod fecundity potential through enhanced heat shock protein insert ignore into journalissuearticles values(HSP-70); production. The structure of ligand insert ignore into journalissuearticles values(bioactive compounds from microalgae); and hsp-70 obtained from the databases of PubChem and Protein Data Bank insert ignore into journalissuearticles values(PDB);, respectively. Molecular Docking was performed by GOLD software and ligand interaction pathways using web server MANORAA. Fourteen bioactive compounds showed good biding interaction with specific protein HSP-70 and seven of these compounds showed high hydrogen bond interaction with key amino acids insert ignore into journalissuearticles values(phenylalanine, tyrosine and tryptophan);. The highest binding energy of 50.21 is recorded in the bioactive compound, arachidonic acid from the red alga Porphyridium cruentum TYR 167 involved in the biosynthesis pathway of phenylalanine, tyrosine and tryptophan also showed specific target site of tryptophan synthase insert ignore into journalissuearticles values(4.2.1.20);. Results suggest with P. cruentum feed copepod culture could boost their fecundity leading to high density culture.
Keywords : Copepod, Microalgae, Arachidonic acid, Porphyridium cruentum, HSP 70