Inflammatory Colitis Due to Methotrexate Toxicity in a Patient With Psoriasis: A Case Report

Authors : Gizem KİLİNC, Ayberk DURSUN, Korhan TUNCER, Hüseyin ESİN, Mustafa EMİROĞLU

Pages : 41-43

Doi:10.37990/medr.766601

View : 33 | Download : 5

Publication Date : 2021-01-23

Article Type : Other Papers

Abstract :Methotrexate is known as a folate antimetabolite. The side effects of methotrexate are not usually seen in low dosages. Here we present a patient with inflammatory colitis due to methotrexate use for psoriasis. A 29 year-old male who was diagnosed with psoriasis 1 year ago and started to use methotrexate for 2 weeks; applied to emergency with acute abdomen symptoms. According to the tests and examinations the patient was diagnosed with inflammatory colitis due to methotrexate toxicity. The patient was observed for abdominal pain without surgical interventions and had folic acid therapy combined with empiric antibiotherapy. Methotrexate side effects are usually seen as bone marrow suppression and mucosal tissue inflammation therefore some side effects can be missed in clinical examinations. As a result, we should consider that in patients applying to emergency with acute abdomen symptoms drugs can be the cause of this clinical presentation. 
Keywords : inflammatory colitis, Methotrexate toxicity, psoriasis