Long-Term Effects of Neonatal LPS and Caspase -1 İnhibitor Administration on Gonadotropin Levels and Testicular Histology in Rats

Authors : Tuba ÖZGÖÇER, Sedat YILDIZ, Azibe YILDIZ, Nigar VARDI

Pages : 22-28

Doi:10.37990/medr.783590

View : 17 | Download : 3

Publication Date : 2021-01-23

Article Type : Research Paper

Abstract :Aim: Endotoxins insert ignore into journalissuearticles values(lipopolysaccharides, LPS); negatively affect reproduction by decreasing gonadotropin levels in the acute period. The aim of this study is to investigate the long-term effects of re-injection of endotoxin in adulthood on gonadotropin release and testicular tissue in male rats injected with endotoxin with IL-1 beta inhibitor insert ignore into journalissuearticles values(Q-Vd-OPh; caspase-1 inhibitor, Cİ); in the neonatal period. Material and Methods: On postnatal day 7, male rat pups were injected once with either Salin, LPS insert ignore into journalissuearticles values(50µg/kg);, LPS insert ignore into journalissuearticles values(50µg/kg);+CI insert ignore into journalissuearticles values(1mg/kg);. On postnatal 10 months, these rats were either injected with saline or LPS insert ignore into journalissuearticles values(50 µg/kg);. 10 days after these injections, serum samples and testicular tissues were taken and the experiment was terminated. Results: Respectively, control, Salin+LPS, LPS+Salin; LPS+LPS; LPSinsert ignore into journalissuearticles values(CI);+Salin and LPSinsert ignore into journalissuearticles values(CI);+LPS groups were 18.8±1.6; 11.3±1.2; 23.4±2.0; 22.2±1.2 ve 23.6±1.4 ng/ml for serum LH concentrations insert ignore into journalissuearticles values(p<0,05);; while 33.4±2.5; 29.6±1.4; 32.1,6±2.0 28.7 0.8 and 35.5±3.3 ng/ml for FSH concentrations insert ignore into journalissuearticles values(p>0,05);. Seminiferous tubule damage was observed in LPS groups insert ignore into journalissuearticles values(p<0,05);. Conclusion: This research demonstrates insert ignore into journalissuearticles values(1); neonatal LPS injections do not negatively affect gonadotropin release in the long term, insert ignore into journalissuearticles values(2); IL-1 β plays a critical role in the programming of reproduction, especially in terms of testicular histology.
Keywords : neonatal LPS, LH, FSH, seminiferous tubules, caspase 1 inhibitor