Second Allogeneic Stem Cell Transplantation in Acute Leukemia with Post-Transplantation Relapse

Authors : Zeynep Tuğba GÜVEN, Serhat ÇELİK, Bülent ESER, Mustafa ÇETİN, Ali ÜNAL, Leylagül KAYNAR

Pages : 455-9

Doi:10.37990/medr.1259944

View : 55 | Download : 98

Publication Date : 2023-09-18

Article Type : Research Paper

Abstract :Aim: It is known that the prognosis of acute leukemia patients who relapse after the first allogeneic stem cell transplantation insert ignore into journalissuearticles values(ASCT); is dismal. Our goal was to assess the value of a second allogeneic stem cell transplant in acute leukemia patients who experienced post-transplant recurrence. Material and Methods: We retrospectively reviewed data from 29 patients with relapsing acute leukemia who underwent a second ASCT. Nineteen patients with acute myeloid leukemia and ten patients with acute lymphoblastic leukemia were included in the study. Results: Ten AML patients and 10 ALL patients were included in the study. Most patients insert ignore into journalissuearticles values(62%); were in remission before the second transplantation. The median time between the first and second ASCT was 11.9 months insert ignore into journalissuearticles values(3.1-42 months);. Complete remission insert ignore into journalissuearticles values(CR); was achieved after the second ASCT in 21 insert ignore into journalissuearticles values(72%); patients, and 11 insert ignore into journalissuearticles values(52%); patients relapsed after the second ASCT. During this analysis, six patients insert ignore into journalissuearticles values(21%); were alive and in remission. Relapse of the disease was the leading cause of mortality. After the second ASCT, overall survival insert ignore into journalissuearticles values(OS); was 6.34 months, and leukemia-free survival insert ignore into journalissuearticles values(LFS); was 13.8 months. Conclusion: For patients with acute leukemia who relapsed after the first ASCT, a second ASCT is a good option and can keep patients alive.
Keywords : Post transplantation relapse, second transplantation, acute leukemia