Examining the Impact of Maternally Administered Bisphenol-A on Rat Kidney Development

Authors : Dilek MEYDAN, Semih TAN, Saim ÖZDAMAR, Hülya ÇETİN

Pages : 559-66

Doi:10.37990/medr.1316792

View : 22 | Download : 34

Publication Date : 2023-09-18

Article Type : Research Paper

Abstract :Aim: Bisphenol-A insert ignore into journalissuearticles values(BPA); is an estrogenic chemical used today in the production of epoxy resin and as an additive in other non-polymer plastics. Due to the widespread use of BPA today, human exposure is inevitable. This exposure causes harmful effects on various body systems. The aim of this study is to investigate the effects on the development of the kidneys of the offspring of mother rats exposed to BPA during pregnancy and lactation, as a result of the offspring being exposed to BPA through the placenta and milk. Material and Methods: In this study, 13 adult Wistar albino female rats were divided into 3 groups. In Group 1 insert ignore into journalissuearticles values(Control group);, rats were only administered 1 ml/kg/day corn oil intraperitoneally. Group 2 insert ignore into journalissuearticles values(25 mg BPA group); rats were administered 25 mg/kg/day BPA; Group 3 insert ignore into journalissuearticles values(50 mg group); rats were administered 50 mg/kg/day BPA intraperitoneally for 5 weeks. At the end of the experiment, the intracardiac blood and kidney tissues of the offspring rats were taken and examined for urea, total protein, creatinine, TAS, TOS, MDA values. Results: At the end of the study, it was determined that BPA increased serum urea, creatinine and total protein levels, induced the formation of reactive oxygen species causing oxidative damage in kidney tissue, and caused serious structural damages Conclusion: Only mother rats exposed to BPA. BPA transferred to pups via placenta and milk, causing structural damage: narrowing in Bowman\`s space of renal corpuscle, dilatation in proximal/distal tubules and collecting ducts, occasional cell loss, vacuolization in tubule epithelia.
Keywords : Bisfenol A, üre, kreatinin, oksifatif stress