Effects of Propolis on Serum Biochemical Parameters in Azaserine Treated Rats

Authors : Hasan YILDIZ, Ümit MİÇOOĞULLARI

Pages : 89-96

Doi:10.28978/nesciences.1142700

View : 12 | Download : 9

Publication Date : 2022-08-08

Article Type : Research Paper

Abstract :Azaserine insert ignore into journalissuearticles values(o-diazoacetyl-L-serine); is an antimetabolite obtained from streptomycetes cultures and is used experimentally to produce atypical acinar cell focus insert ignore into journalissuearticles values(AACF); in rat exocrine pancreas. Propolis is a resinous hive product with antioxidant, anticarcinogenic, antimicrobial and anti-inflammatory effects that bees collect from the plants around them. In this study, we aimed performed to investigate the effect of ethanol extract of propolis insert ignore into journalissuearticles values(EEP); on serum biochemical changes in azaserin induced pancreatic cancer in Wistar rats. For this purpose, male Wistar albino rats were randomly divided into 4 groups, 10 in each group. AzCt and AzProp group 2-week-old male rats were given azaserine insert ignore into journalissuearticles values(30 mg/kg bw); intraperitoneally insert ignore into journalissuearticles values(ip);. Propolis insert ignore into journalissuearticles values(EEP); insert ignore into journalissuearticles values(oral 80 mg/lt); was added to the drinking water of Prop and AzProp group rats. For the first time in this study, the effects of propolis on rats with neoplastic structures formed by azaserine were investigated in terms of biochemical parameters insert ignore into journalissuearticles values(AST, ALP, ALT, BILD, BILT, CHOL, LDH, TRIG, UREA, TAS, TOS and OSI);. According to this; AzProp group values were compared to AzCt group, respectively, AST, UREA, TOS and OSI, there is a statistically significant difference in terms of values. As a result, it was seen that the oxidative stress caused by azaserine-induced neoplastic structures decreased with the use of propolis and that propolis had a positive effect on the measured biochemical parameters.
Keywords : Azaserine, propolis, serum, oxidative stress