Effect of Curcumin on Testis in Mice with Ehrlich Ascites Tumor

Authors : Seher YİLMAZ, Yeşim GÖÇMEN, Adem TOKPINAR, Şükrü ATEŞ, Mustafa NİSARİ, Aysen CANİKLİOĞLU, Ünal ÖZTEKİN

Pages : 53-58

View : 14 | Download : 12

Publication Date : 2020-09-30

Article Type : Research Paper

Abstract :In the current work, the effects of curcumin on testicular tissues in Ehrlich Ascites Tumor insert ignore into journalissuearticles values(EAT); model developed in Balb/C mice. EAT cells insert ignore into journalissuearticles values(1x106); received from stock of animals were injected intraperitoneally to animals. 25mg/kg and 50mg/kg of curcumin was administered intraperitoneally. Testicular tissues obtained after all the experiment were evaluated for histopathological and biochemical parameters. Histopathological results showed that 50 mg/kg curcumin group had less EAT cells around testicular tissues than tumor control group. Superoxide dismutase insert ignore into journalissuearticles values(SOD);, catalase insert ignore into journalissuearticles values(CAT);, glutathione peroxidase insert ignore into journalissuearticles values(GPx); activities and reduced glutathione insert ignore into journalissuearticles values(GSH);, oxide glutathione insert ignore into journalissuearticles values(GSSG);, total antioxidant status insert ignore into journalissuearticles values(TAS);, total oxidant status insert ignore into journalissuearticles values(TOS);, interleukin-1beta insert ignore into journalissuearticles values(IL-1β);, interleukin-6, interleukin-17, tumor necrosis factor-alfa insert ignore into journalissuearticles values(TNF-α); levels were measured in testis tissues. Oxidative stress index insert ignore into journalissuearticles values(OSI); and GSH/GSSG ratio were calculated. Findings clearly suggested that antioxidant parameters insert ignore into journalissuearticles values(except CAT and GPx); had higher value in animal models treated with 25 and 50 mg curcumin groups associated to tumor control group. There was a statistically noteworthy variance between the groups in all parameters. Antitumor effect of curcumin on ascites tumor cells produced by EAT cells evidenced with histopathological while antioxidant and anti-inflammatory biochemical parameters evidenced with biochemical parameters.
Keywords : Testis, EAT, Mice, Curcumin, Antioxidant