Clinical Presentation of Neuropsychiatric Systemic Lupus Erythematosus and Demographic and Radiological Characteristics of Patients

Authors : Fatma ŞİMŞEK, Mustafa CEYLAN

Pages : 123-129

View : 11 | Download : 7

Publication Date : 2021-09-15

Article Type : Research Paper

Abstract :Introduction: Systemic lupus erythematosus insert ignore into journalissuearticles values(SLE); is a vasculitis that may affect numerous systems such as the kidneys, skin, joints, heart, lungs and nervous system. The purpose of our study is to evaluate patients with SLE in whom central nervous system involvement is monitored. Material and method: Files of 1028 patients who were followed up with systemic lupus erythematosus insert ignore into journalissuearticles values(SLE); diagnosis have been reviewed. Demographic, clinical and radiological characteristics were recorded for patients with a final diagnosis of neuropsychiatric systemic lupus erythematosus insert ignore into journalissuearticles values(NPSLE); with central involvement. Results: Among 1028 patients diagnosed with SLE, 1.07% had NPSLE. Mean age was 37+5.3. 90.9% of the patients insert ignore into journalissuearticles values(n = 10); were female, while 9.1% insert ignore into journalissuearticles values(n = 1); were male. From a clinical aspect, 45.4% complained from hemiparesis, 27.3% from headache, 18.2% from psychiatric complaints and 9.1% complained from impairment of consciousness. From a radiological aspect, 45.4% insert ignore into journalissuearticles values(n=5); were consistent with subcortical plaque, 36.4% insert ignore into journalissuearticles values(n=4); with ischemic stroke, 9.1% insert ignore into journalissuearticles values(n=1); with cerebral venous thrombosis, and 9.1% insert ignore into journalissuearticles values(n=1); appeared consistent with posterior reversible encephalopathy syndrome insert ignore into journalissuearticles values(PRES);. Mortality rate was 9.1% insert ignore into journalissuearticles values(n=1);. The central involvement type that caused mortality was ischemia. Conclusion: Since magnetic resonance imaging insert ignore into journalissuearticles values(MRI); is not sufficient for showing microvascular involvement in NPSLE patients, it is possible for NPSLE diagnosis to be delayed despite consistent clinical characteristics. In case of clinical suspicion, other imaging methods should be applied apart from MRI. This is because early diagnosis is an important factor that reduces morbidity and mortality.
Keywords : Systemic Lupus Erythematosus, , Central Nervous System, , Magnetic Resonance Imaging