Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach

Authors : Selçuk YILMAZ, Hasan ŞİMŞEK, Sefa KÜÇÜKLER, Serpil AYGÖRMEZ, Ender ERDOĞAN, Fatih Mehmet KANDEMİR

Pages : 149-155

Doi:10.56766/ntms.1325124

View : 57 | Download : 48

Publication Date : 2023-09-21

Article Type : Research Paper

Abstract :Aim: Cancer is a disease that is on the rise worldwide. Paclitaxel insert ignore into journalissuearticles values(PTX); is one of the most common chemotherapeutic agents used in the treatment of many cancers. PTX causes toxic effects by increasing oxidative stress in tissues. Naringin is a powerful antioxidant found naturally in many plants, especially citrus fruits. The aim of this study was to determine the protective effects of NRG in PTX-induced sciatic nerve injury. Methods: Thirty-five male rats were randomly divided into five groups: control, PTX, NRG, PTX+NRG-50, PTX+NRG-100. PTX was administered i.p. for the first five days and NRG 50 or 100 mg/kg orally on days 6-14. Sciatic nerve tissues were harvested and analyzed for markers of oxidative stress, inflammation and apoptosis damage levels by biochemical methods. Results: PTX caused oxidative stress damage by increasing lipid peroxidation insert ignore into journalissuearticles values(MDA); and decreasing antioxidant capacity insert ignore into journalissuearticles values(SOD, CAT, GPx and GSH);, inflammatory damage by increasing proinflammatory cytokine insert ignore into journalissuearticles values(NF-κB, TNF-α, IL-1β, SIRT1, TLR4, and NRF2); release, apoptotic damage by increasing apoptotic factor insert ignore into journalissuearticles values(Bax); and decreasing antiapoptotic factor insert ignore into journalissuearticles values(Bcl-2); in sciatic nerve tissue insert ignore into journalissuearticles values(p < 0.05);. NRG, on the other hand, reversed all these changes in sciatic nerve tissue and reduced PTX-induced oxidative stress damage, inflammatory damage and apoptotic damage insert ignore into journalissuearticles values(p < 0.05);. These effects were more effective at the 100 mg/kg dose of NRG than at the 50 mg/kg dose insert ignore into journalissuearticles values(p < 0.05);. Conclusions: In sciatic nerve tissue, PTX induced peripheral neuropathy with increased oxidative stress, inflammation and apoptotic damage. NRG showed a protective effect against PTX-induced peripheral neuropathy.
Keywords : Apoptosis, Naringin, Oxidative stress, Paclitaxel, Sciatic nerve