BUDESONIDE SELF-NANOEMULSION FORMULATION AS AN ORAL DRUG DELIVERY SYSTEM: PREPARATION, CHARACTERIZATION AND CYTOTOXICITY STUDIES

Authors : Burcu Mesut, Seyma Hande Tekarslan Sahin, Yildiz Ozsoy

Pages : 41-46

Doi:10.17261/Pressacademia.2017.569

View : 17 | Download : 6

Publication Date : 2017-06-30

Article Type : Research Paper

Abstract :Lipophilic drugs which are poorly water soluble need specific applications like lipid based delivery systems to increase their oral absorption across gastrointestinal tract. Selfnanoemulsifying drug delivery systems are Lipid Based Drug Delivery systems insert ignore into journalissuearticles values(SNEEDs); and are consists of an isotropic mixture of oil, surfactantinsert ignore into journalissuearticles values(s); and co-surfactant. This drug delivery systems are prepared at room temperature with gentle stirring process without using any other component or heating process and become nanoemulsion form upon gentle agitation in aqueous phase.  SNEDDs have many advantages such as they can be produced easily and they are affected less from other outside factors, its scaleup process is easy, unaffected by lipid digestion, carry and protect peptides which can be enzymatically hydrolyzed. The aim of this study was to increase solubility of Budesonide by using new Snedds formulation approach.  
Keywords : Budesonide, self nanoemulsion drug delivery, oral drug delivery, cytotoxicity