Obese Boys Wıth Low Concentratıons of Hıgh Densıty Lıpoproteın Cholesterol are at Greater Rısk of Hepatosteatosıs

Authors : Elif ÖZSU

Pages : 404-409

View : 12 | Download : 6

Publication Date : 2019-12-10

Article Type : Conference Paper

Abstract :Purpose: Non-alcoholic fatty liver disease insert ignore into journalissuearticles values(NAFLD); and associated morbidities have become a public health problem due to a global three-fold increase in incidence among obese children over the last three decades. Although the gold standard for diagnosis of NAFLD is liver biopsy, it is not widely used in children. Imaging techniques, including magnetic resonance and ultrasound, can provide information on liver fat deposition, with variable sensitivity. Therefore, a number of other predictors are being investigated for pediatric screening and diagnostic purposes. The aim of this study was to assess easily measured parameters to prompt further investigation for NAFLD in obese children. Methods: Obese children/adolescents with a Body Mass Index insert ignore into journalissuearticles values(BMI); percentile >95 were enrolled in the study insert ignore into journalissuearticles values(n=353);. After a 12-hour fast, venous glucose, insulin, cholesterol, triglycerides insert ignore into journalissuearticles values(TG);, high density lipoprotein insert ignore into journalissuearticles values(HDL);, low density lipoprotein insert ignore into journalissuearticles values(LDL); and uric acid were measured and full blood count was performed in all subjects. The TG/LDL ratio, the AST/platelet ratio index insert ignore into journalissuearticles values(APRI score); and the Homeostatic Model of Assessment-Insulin Resistance insert ignore into journalissuearticles values(HOMA-IR); were calculated. All patients underwent abdominal ultrasound examination to assess heaptosteatosis. Results: Of 353 patients, median age 12.5 insert ignore into journalissuearticles values(range: 6-17.9); years, 210 insert ignore into journalissuearticles values(59%); patients had US-proven hepatosteatosis. Female gender reduced the risk of steatosis 2.08 fold insert ignore into journalissuearticles values(p=0.005);, one unit increase in HDL reduced the risk of steatosis 1.02 fold insert ignore into journalissuearticles values(p=0.042); and one unit increase in the BMI led to a 1.11 fold insert ignore into journalissuearticles values(p=0.002); increase in the risk of steatosis. Conclusion: Gender, BMI and HDL were found to be predictors of steatosis. Male patients with low HDL and high BMI are at greater risk of steatosis and should be carefully examined for the presence of NAFLD.
Keywords : Fatty liver, childhood, high density lipoprotein, hepatosteatosis, obesity