Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas

Authors : Neşe YELDİR, Ezgi DOĞAN, Hatice ÖZER, Burçak SÖYLEMEZ, Serkan ÇELİKGÜN, Reyhan EĞİLMEZ

Pages : 43-50

Doi:10.47493/abantmedj.1177937

View : 22 | Download : 6

Publication Date : 2023-04-28

Article Type : Research Paper

Abstract :Objective: Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization insert ignore into journalissuearticles values(WHO); classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit insert ignore into journalissuearticles values(cut-off); value of the Ki-67 proliferation index in cases diagnosed with meningioma. Materials and Methods: The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. Results: The mean Ki-67 proliferation index was found to be 6.3% for grade 1, 11.2% for grade 2 and 26% for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6.5 insert ignore into journalissuearticles values(p>0.05);. Conclusion: The Ki-67 proliferation index in meningioma is an important parameter that can be used to determine the histological grade of atypical meningioma in particular. Although the index seems to be easy to use, it is a value that can create difficulties in borderline cases and also in interobserver and intraobserver evaluations. Therefore, each pathology laboratory should determine the Ki-67 value that they can accept as a limit for meningioma grading.
Keywords : Meningiom, ROC analizi, Pozitiflik sınır değeri