Claudin 18.2 Expression in Gastric Adenocarcinomas in a Large Turkish Cohort

Authors : Aynur IŞIK, Güneş GÜNER, Can ZEYNELOĞLU, Seçil DEMİRKOL CANLI, Hakki TASTAN, Aytekin AKYOL

Pages : 122-130

Doi:10.47493/abantmedj.1313791

View : 82 | Download : 74

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Background: Claudin 18.2 insert ignore into journalissuearticles values(CLDN18.2); is a tight junction protein expressed especially in gastric adenocarcinomas. The prognostic and clinicopathologic implications of CLDN18.2 expression is currently unknown. Zolbetuximab monoclonal antibody against CLDN18.2 is under investigation as a potential treatment for advanced gastric cancer insert ignore into journalissuearticles values(GC);. We aimed to investigate the impact of CLDN18.2 expression in GC on prognosis and tumor features in a large Turkish cohort. Methods: Seven tissue microarrays insert ignore into journalissuearticles values(TMAs); containing 263 cases of GC were constructed. Assessment of CLDN18.2 expression was performed by immunohistochemistry, where it was scored as negative and positive. Results: 14.3% insert ignore into journalissuearticles values(37/258); of GCs were stained with anti-CLDN18.2 antibody. While 7.8% insert ignore into journalissuearticles values(20/258); of all cases were positive, 92.2% insert ignore into journalissuearticles values(238/258); were scored as negative. There was no statistically significant difference between the two groups in terms of patient features such as age or sex, tumor grade, TNM stage, histologic subtype or overall survival. Conclusion: CLDN18.2 expression was not associated with patient prognosis in the Turkish cohort. However, as this molecule is a potential therapeutic target, information about the impact of CLDN18.2 expression will be important in managing patients, therefore more studies are needed to learn more on the outcomes of CLDN18.2 expression on clinicopathologic features in GC.
Keywords : Gastrik kanser, CLDN18 2, biomarker