A Retrospective Study on Kidney Transplant Recipients Diagnosed with COVID-19

Authors : Huseyin Celik, Mahmut Esat Danisoglu, Ender Hür, Murat Şamlı, Bulent Oktay, Soner Duman

Pages : 24-31

Doi:10.47493/abantmedj.1375704

View : 64 | Download : 112

Publication Date : 2024-04-30

Article Type : Research Paper

Abstract :Background and objective: Solid organ transplantation may prone to coronavirus disease-2019 (COVID-19) infections. It was aimed to present outcomes of kidney transplant recipients diagnosed with COVID-19. Methods: In this retrospective cohort study was used 1034 kidney transplant recipients’ files from a center, 95 were diagnosed COVID-19 between March 1, 2020, and March 31, 2021. Patients were divided as survivors and non survivors. Statistically student t test was done and p<0.05 level was accepted as significant. Results: In 95 patients, 58 (61%) were male with a mean age of 48.6±11.2 years, cadaveric transplantation 31 (32.6%). Symptoms were similar in overall; fever 31%, cough 39%, myalgia 59%, diarrhea 20%, but all non-survivor group having dyspnea than 24% of survivor group (p<0.05). Mortality was 12 (12.6%), non-survivors were older 55.89±6.99 vs 47.56±11.33 years (p<0.05), body mass index higher 28.8 ± 5.5 vs 25.5 ± 5.0 kg/m2 (p< 0.05), diabetes more prominent 50 to 30% (p< 0.05), hospitalization were longer 8.5±10.6 vs 3.05±5.93 days (p< 0.01) in non-survivors. In non-survivors’ leukocytosis 15.24±8.80 vs 7.13±3.39 (/mm3), increased liver function tests ALT and AST 632±1041 and 2722±4662 vs 22.8±16.8 and 23.3±12.6 (U/L) (p<0.001), ferritin 2301.3±1349.1 vs 898.4±1007.6 (ng/ml) (p< 0.05). Lactate dehydrogenase 554±305 vs 252±130 (mg/dl) (p<0.001), Procalcitonin 1.310±1.285 vs 0.108±0.105 (ng/ml) (p<0.000). estimated glomerular filtration rate levels decreased 11.12±1.89 vs 50.75±21.99 ml/min (p<0.05). All non-survivors and 2% of survivors needed hemodialysis. Survival was lower in cadaveric patients significantly in Kaplan Meier analysis (p<0.05). Conclusion: Renal transplant recipients with COVID-19 have increased rate of acute kidney injury and mortality and survival was lower in cadaveric patients.
Keywords : Akut böbrek hasarı, Coronavirüs 19 Hastalığı, , Böbrek nakli alıcıları