DENEYSEL ARTRİT MODELİNDE İNTRAARTİKULER HYALURONIK ASİT VE METİL PREDNİSOLON ASETATIN SiNOVYAL DOKU UZERİNE ETKİLERİ / EFFECTS OF INTRAARTICULAR HYALURONIC ACID AND METHYL PREDNISOLONE ACETATE ON SYNOVIAL TISSUE IN A MODEL OF EXPERIMENTAL ARTHRITIS

Authors : Şirzat Çoğalgil, Orhan Karsan, Lale Cerrahoğlu, Halis Süleyman, Cemal Gündoğdu, Fazlı Erdoğan

Pages : 0-0

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Publication Date : 2010-02-20

Article Type : Research Paper

Abstract :Intraartikuler olarak uygulanan hyaluronik asit insert ignore into journalissuearticles values(HA); ve metil prednisolon asetat insert ignore into journalissuearticles values(MPA); tedaviJennin enf1amatuar artritler uzerine olan etkilerini ara$tlrmak iyin deneysel bir yall$ma yaplldl. 40 adet erkek ratm sag arka diz eklemleri ir:ine 0.2 ml %1\`Iik formalin venlerek deneysel artnt olu$turuldu. Ilay veriJmesinden bir hafta sonra 10 rat oldtJrulerek artritin olu$tugu histopatolojik olarak belirlendi. Kalan 30 rat 3 gruba aynldl. Birinci gruba 005 ml intraartikuler HA insert ignore into journalissuearticles values(HA grubu);, ikinci gruba 0.05 ml intraartikuler MPA insert ignore into journalissuearticles values(MPA grubu); verildi. Uyuncu gruba ise intraartikuler 0.05 ml serum fizyolojik verilerek kontrol grubu Olu$turuldu. Tedaviler artrit olu§turulduktan sonra 7. Gun, 14. Gun ve 21. gun uygulandl. Uygulanan bu tedavilerin bitiminden 15 gun sonra rat/ar oldunJldtJ ve alman omekler, histopatolojik olarak incelendi. YapiJan incelemede; HA tedavisi ile sinovyal dokuda kontrol grubuna gore anlamll iyile$me olmad/gl goruldu insert ignore into journalissuearticles values(p>0.05);. MPA grubunda ise sinovyal doku iyile§mesi kontrol grubuna gore anlam\` olarak yuksek bulundu insert ignore into journalissuearticles values(p<0.05);. Ancak her iki tedavi grubu kar§/Ia§tmld/gmda MPA ve HA grubu arasmda anlaml/ fark bulunamad/ insert ignore into journalissuearticles values(p>0.05);. Enflamatuar artrit tedavisinde intraartikuJer olarak uygulanan MPA\`m sinovyal doku iyile§mesinde daha etkili glbi gorunmesine ragmen, HA\`e gore banz bir ustUnlugunun olmad/gl sonucuna vanldl. Anahtar kefimefer: Deneysel artrit, sinovyal doku, hyaluronik asit, metil prednisolon asetat. SUMMARY This experimental study was performed to determine the effects of intraarticular hyaluronic acid insert ignore into journalissuearticles values(HA); and methyl prednisolone acetate insert ignore into journalissuearticles values(MPA); in inflammatory arthritis. 0.2 ml1% formaline were injected to the posterior right knee joints of 40 male rats. One week after the injections, 10 rats were killed and arthritis was determined histopathologically. The remained 30 rats were divided to three groups. First group received intraarticularly 0.05 ml HA insert ignore into journalissuearticles values(HA group);, second group 0.05 ml MPA insert ignore into journalissuearticles values(MPA group); and third group 005 ml saline as controls. The injections were performed at 7., 14. and 21. days after the arthritis. 15 days after the end of these treatments, rats were killed and sections were examined histopathofogically. There was no significantly difference in synovial tissue healing between HA and control groups insert ignore into journalissuearticles values(p>0.05);. Synovial tissue healing was significantly high in MPA group compared to the control group insert ignore into journalissuearticles values(p<0.05);. However in comparing the two treatment groups insert ignore into journalissuearticles values(MPA and HA groups); there was not any significant difference insert ignore into journalissuearticles values(p>0.05);. It was concluded that although intraarticular MPA seems more effective on synovial tissue healing in inflammatory arthritis it has no evident superiority to HA. Key Words: Expen\`mental arthritis, synovial tissue, hyaluronic acid, methyl prednisolone acetate
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