Unifying Mechanism for Eye Toxicity: Electron Transfer, Reactive Oxygen Species, Antioxidant Benefits, Cell Signaling and Cell Membranes

Authors : Peter Kovacic, Ratnasamy Somanathan

Pages : 56-69

View : 15 | Download : 5

Publication Date : 2013-08-13

Article Type : Conference Paper

Abstract :Eye toxicity comprises an important part in the category of insults to major organs. There is considerable literature comprising industrial chemicals, atmospheric pollutants, metals, pesticides, therapeutic drugs, abused drugs and household chemicals. The list includes both endogenous and exogenous materials. The various constituents of the eye are affected. This review provides extensive evidence for involvement of oxidative stress insert ignore into journalissuearticles values(OS); and electron transfer insert ignore into journalissuearticles values(ET); as a unifying theme. Successful application of the mechanistic approach is made to all of the main classes of toxicants, in addition to large numbers of miscellaneous types. We believe it is not coincidental that the vast majority of these substances incorporate ET functionsinsert ignore into journalissuearticles values(quinone, metal complex, ArNO2, or conjugated iminium); either per se or in metabolites, potentially giving rise to reactive oxygen species insert ignore into journalissuearticles values(ROS); by redox cycling. Some categories, e.g., peroxide and radiation, appear to generate ROS by non-ET routes. Beneficial effects of antioxidants are documented extensively, in addition to literature on cell signaling.
Keywords : eye toxins, electron transfer, oxidative stress, antioxidants, cell membranes