Multivitamin-mineral supplement is more efficacious than vitamins (E+C) in the prevention of chronic unpredictable stress induced oxidative damage in mice

Authors : Shirin HASAN, Nayeem BİLAL, Sabiha FATİMA, Nida SUHAİL, Khalid ANWAR, Sadhana SHARMA, Naheed BANU

Pages : 125-132

View : 17 | Download : 8

Publication Date : 2013-08-14

Article Type : Research Paper

Abstract :Stress triggers a physiological response by increasing the metabolic rate which translates into oxidative stress, resulting in the etiopathogenesis of many diseases. Several micronutrients like antioxidant vitamins and minerals can modulate the state of oxidative stress. This study tests whether an MM insert ignore into journalissuearticles values(consisting of functionally diverse dietary antioxidants); compares favourably with a combination of vitamins E and C, in providing increased anti-oxidative protection against chronic unpredictable stress insert ignore into journalissuearticles values(CUS); induced oxidative damage in mice. Thirty-two Swiss albino mice were randomized to one of the following groups: control+vehicle, CUS+ vehicle, CUS+ MM, and CUS+ vitamins insert ignore into journalissuearticles values(C+E);. CUS was applied for 4 weeks and MM and vitamins insert ignore into journalissuearticles values(C+E); were administered orally for the same period. CUS led to a negative impact on all the biochemical parameters analyzed in circulation, liver and kidney with elevation of malondialdehyde and reduction of glutathione levels. The activities of superoxide dismutase, catalase, glutathione S-transferase, and glutathione reductase were decreased by CUS, with an elevation of liver marker enzymes, glutamate oxaloacetate transaminase insert ignore into journalissuearticles values(GOT); and glutamate pyruvate transaminase insert ignore into journalissuearticles values(GPT); in the circulation and liver. Supplementation with MM and vitamins insert ignore into journalissuearticles values(C+E); restored the disturbed antioxidant status in the stress exposed mice. However, MM was found more effective than vitamins insert ignore into journalissuearticles values(C+E); in reinstating the altered parameters. The results of the study suggest that the cumulative action of diverse vitamins and minerals in an MM exert greater antioxidative effect than vitamins insert ignore into journalissuearticles values(C+E); in combating the CUS induced oxidative stress, thus supplementation of MM alone can be an effective measure to combat stress induced oxidative derangements both under normal and pathological conditions.
Keywords : Ion channels, cell biochemistry, biophysics, calcium signaling, cellular function, cellular physiology, metabolism, apoptosis, lipid peroxidation, nitric oxide synthase, ageing, antioxidants, neuropathy