Relationship between some element levels and oxidative stress parameters in rats liver treated with hydroxyurea derivative compounds

Authors : Yusuf KARAGÖZOĞLU, Akif Evren PARLAK, Naci Ömer ALAYUNT, Semra TÜRKOĞLU, İsil YİLDİRİM, Mustafa KARATEPE

Pages : 797-804

Doi:10.37212/jcnos.579145

View : 15 | Download : 6

Publication Date : 2019-06-18

Article Type : Research Paper

Abstract :In this study, effects of hydroxyurea derivatives 1, 3, 4 - thiadiazole and schiff base compounds on some element levels and antioxidant enzyme activities in rat liver and on antioxidant enzyme levels that are parameters of oxidative stress were investigated. For this purpose, iron insert ignore into journalissuearticles values(Fe);, zinc insert ignore into journalissuearticles values(Zn); and copper insert ignore into journalissuearticles values(Cu); concentrations were analyzed by using atomic absorption spectroscopy superoxide dismutase insert ignore into journalissuearticles values(SOD); and catalase insert ignore into journalissuearticles values(CAT); activities were measured by using a UV spectrophotometer. Fe, Zn and Cu concentrations in the liver of rats treated with these compounds were compared with levels of SOD and CAT statistically. As a result, the increase in the antioxidant activities of SOD and CAT metalloenzymes together with decrease in levels of Cu, Zn and Fe elements observed may suggest that the elements be bound to these enzymes. 
Keywords : Some element, oxidative stress, rat, liver