Is Hypericum perforatum agonist or antagonist of TRPC6 in neurons?

Authors : Mustafa NAZIROĞLU

Pages : 595-600

Doi:10.37212/jcnos.334114

View : 16 | Download : 7

Publication Date : 2016-12-31

Article Type : Review Paper

Abstract :Transient receptor potential canonical 6 insert ignore into journalissuearticles values(TRPC6); channel is a family of transient receptor superfamily. Hyperforin is an active component of Hypericum species including Hypericum perforatum insert ignore into journalissuearticles values(HPer);. In the review paper, t he author summarizes the recent information between TRPC6-induced Ca 2+ entry, HPer and hyperforin to understand the etiology of the neurological diseases and potential therapeutic strategies . The TRPC6 in several cell types is activated by 2-Aminoethoxydiphenylborane insert ignore into journalissuearticles values(2-APB);, 4,5 triphosphate insert ignore into journalissuearticles values(IP 3 );   and diacylglycerol insert ignore into journalissuearticles values(DAG); pathways, although it was inhibited in the cells by several non-specific antagonists including gadolinium and lanthanum. Results of limited studies indicated that hyperforin caused intracellular Ca 2+ elevations through TRPC6 activation in neurons and cells , although the intracellular Ca 2+ elevation results were not confirmed by many recent studies. Release Ca 2+ from internal stores instead of extracellular Ca 2+ entry through activation of TRPC6 channel in neurons of brain was also reported. The TRPC6-induced Ca 2+ influx was inhibited in brain by active components of some antioxidants. In conclusion, the present literature information shows that interaction between TRPC6-induced Ca 2+ entry and hyperforin in neurons and cell lines are too complex and it has not been clarified yet.
Keywords : TRPC6, Hypericum perforatum, Hyperforin, Calcium ion