In patients receiving spinal anesthesia, can homocysteine and C-reactive protein levels predict the development of postdural puncture headache?

Authors : Murat ŞAHİN, Kemal PEKER, Ali Seydi BOZKURT

Pages : 34-41

View : 16 | Download : 5

Publication Date : 2019-08-30

Article Type : Research Paper

Abstract :Objectives: Postdural puncture headache insert ignore into journalissuearticles values(PDPH); is a complication that may arise following spinal anesthesia. We investigated whether homocysteine and C-reactive protein levels may be associated in the development of PDPH in patients that received spinal anesthesia. Materials and Methods: In order to determine homocysteine and C-reactive protein insert ignore into journalissuearticles values(CRP); levels, blood samples were taken from patients before and one day following spinal anesthesia. A total of 100 male patients were enrolled in the study. The mean age of the patients was 29 years old. Out of all the patients, a total of 6 developed headaches. The Mann-Whitney U-test was used to compare homocysteine and CRP levels between patients that did and did not develop headaches. Results: Homocysteine levels before and after the operation were higher in subjects that developed a headache as compared to patients that did not develop headaches insert ignore into journalissuearticles values( p <0.001);. CRP levels did not differ significantly between patients with headaches and patients that did not experience them insert ignore into journalissuearticles values( p >0.05);. Conclusions: High blood levels of homocysteine in patients with PDPH might be used as a biomarker so to predict the development of PDPH. However, future larger, multi-center studies are needed to further elucidate this association.
Keywords : Spinal Anesthesia, Postdural Puncture Headache, Homocysteine, C Reactive Proteine