THE ROLE OF NEUTROPHIL TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATION IN DIAGNOSIS OF SUBACUTE THYROIDITIS

Authors : Çiğdem TURA BAHADIR, Merve YILMAZ, Elif KILIÇ KAN

Pages : 46-57

Doi:10.55895/sshs.1096999

View : 14 | Download : 6

Publication Date : 2022-04-30

Article Type : Research Paper

Abstract :Purpose: Patients with subacute thyroiditis insert ignore into journalissuearticles values(SAT); usually apply to clinics with thyrotoxicosis and neck pain. Hemogram is frequently applied tests in primary health care services, and it can warn physicians for SAT in a thyrotoxic patient. In our study, the role and usability of neutrophil to lymphocyte ratio insert ignore into journalissuearticles values(NLR); and platelet to lymphocyte ratio insert ignore into journalissuearticles values(PLR); in the diagnosis of SAT were evaluated. Material and Methods: Between January 2015 and January 2020, 192 SAT patients who applied to endocrinology clinics and 85 healthy control were included in the study. Neutrophil insert ignore into journalissuearticles values(Neu);, lymphocyte insert ignore into journalissuearticles values(Lym);, platelet insert ignore into journalissuearticles values(PLT); leves were recorded. Results: The median NLR and PLR values of SAT patients before treatment were 2.78 insert ignore into journalissuearticles values(0.91-11.33); and 168.3 insert ignore into journalissuearticles values(25.7-818.3);, respectively, and were significantly higher than the control group insert ignore into journalissuearticles values(p<0.001);. The optimum cut-off values for NLR and PLR for SAT were 1.84 insert ignore into journalissuearticles values(specificity 85.9% and sensitivity 90.1%; p<0.001; AUC=0.934; 95% CI: 0.905-0.964 ); and 140.2 insert ignore into journalissuearticles values(specificity 83.5% and sensitivity 77.1%, p<0.001, AUC=0.821 95% CI: 0.767-0.874);, respectively. Pretreatment NLR, PLR, CRP, and ESR levels were significantly higher than the posttreatment levels insert ignore into journalissuearticles values(all p<0.001);. Correlation analysis revealed positive linear relations between pretreatment PLR and CRP insert ignore into journalissuearticles values(p=0.002, r=0.220);, pretreatment PLR and ESR insert ignore into journalissuearticles values(p=0.018, r=0.171);, pretreatment NLR and CRP insert ignore into journalissuearticles values(p<0.001, r=0.330);, and pretreatment NLR and ESR insert ignore into journalissuearticles values(p=0.001, r=0.242);. Multiple linear regression analysis revealed a 0.008 unit of increment of NLR per 1 unit increase in CRP levels insert ignore into journalissuearticles values(B=0.008; p<0.001; %95 CI=0.004-0.012);. Conclusion: High NLR and PLR values accompanying thyrotoxicosis are both warning and helpful parameters for the diagnosis of SAT.
Keywords : Neutrophil to lymphocyte ratio, NLR, painless subacute thyroiditis, platelet to lymphocyte ratio, PLR, subacute thyroiditis