SYNTHESIS AND FUNCTIONAL PROPERTIES OF DIPHENYLAMINE-CONTAINING SCHIFF BASES

Authors : Hasan Ufuk CELEBİOGLU, Ebru KÖROĞLU, Recep TAŞ, Sevilay GÜNAY, Yavuz ERDEN

Pages : 40-55

Doi:10.55930/jonas.1278393

View : 72 | Download : 84

Publication Date : 2023-07-31

Article Type : Research Paper

Abstract :Schiff bases have been widely researched in vitro for their antimicrobial, antitumor, antiviral, antineoplastic, and antioxidant properties, owing to their strong chelating ability. Probiotics refer to “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. Thus, this study aims to investigate the antibacterial, anticancer, and antioxidant effects of Schiff Bases N-methylene-N-phenylbenzenaminium and N-insert ignore into journalissuearticles values(5-oxopentylidene);-N-phenylbenzenaminium, as well as their impact on some properties of probiotic bacteria, Lactobacillus acidophilus and Lacticaseibacillus rhamnosus. Results indicate that these Schiff bases promote the growth of probiotic bacteria while inhibiting pathogenic bacteria. They demonstrate potent antibacterial and antioxidant activities, and cytotoxicity assays reveal that both compounds exert a high degree of inhibition on human colon and breast cancer cells. Additionally, there is significant modulation in auto-aggregation and surface hydrophobicity of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus. In conclusion, the Schiff bases investigated in this study possess significant therapeutic potential.
Keywords : Antibacterial, anticancer, antioxidant, Lactobacillus, probiotics, Schiff bases