Doku Mühendisliğinde Kitozanın Kullanım Alanları

Authors : Bahar USLU, Serap ARBAK

Pages : 128-135

View : 20 | Download : 11

Publication Date : 2010-09-01

Article Type : Other Papers

Abstract :Tissue engineering will provide the most therapeutical strategy of medicine currently and in future. Most of the current investigations concerning regenerative medicine involves development of supporting and structural materials scaffold . Chitosan, as a biomaterial, is a focus of interest in tissue engineering by presenting the following features such as being a natural polymer, having a porous structure, being reliable to chemical modifications, easy-to-use in gel form, being biocompatible, and crating non-toxic metabolites. Derivatives of chitin and chitosan are widely used as biomaterials in many fields. Being cell friendly and easy-to-be degraded by lysosomal activity results in its wide usage in bioengineering. Investigations pointed out its positive effect on tissue growth and tissue layering rates. Possesing a similarity to glycosaminoglycans in tissue matrix, chitosan is defined as a highly suitable biomaterial in connective tissue regenation and organogenesis. In vivo studies represented its effects on increasing number of skin fibroblasts. Membranous form of chitosan has a positive impact on the cellular attachment and penetration. Considerable mitogenic activity of chitosan in tissue engineering is related to its high degree of deacetylisation. Chitosan, as an organic biomaterial, is strongly preserving its current importance strongly based on its flexibility according to different conditions
Keywords : chitosan, tissue engineering, polymer