Dev Hücreli Miyokardite Bağlı Ani Ölüm

Authors : Evrim Akça KAYA, Işıl PAKİŞ, Mehmet ÖZBAY, Yalçın BÜYÜK, Ceyhun KÜÇÜK

Pages : 235-237

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Publication Date : 2010-12-01

Article Type : Other Papers

Abstract :Giant cell myocarditis is a rapidly fatal disorder characterized by the presence of multinucleated giant cells and a lymphocytic inflammatory infiltrate, associated with myocyte necrosis. The diagnosis of giant cell myocarditis is usually determined at autopsy. We present a 35 years old female case of sudden death while playing tennis. On internal examination, the heart weighed 315 g and thickness of left ventricular wall was 1,4 cm ,that of right ventricle was 0,1-0,3 cm. Papillary muscles in both ventricles were fibrotic and showed disarrangement. There was an area of aneurysm with a diameter of 4 cm in left ventricle. Myocardial sections showed areas of fibrosis and dark-mottled areas. Microscopic examination of myocardial sections revealed connective tissue replacing normal myocardial muscle bundles, diffuse lymphohistiositic inflammatory cell infiltration, multinuclear giant cells, and scarce eosinophilic polymorhocytes. Microscopic sections of other internal organs showed no pathology other than hyperemia. On the basis of these findings, the final diagnosis was giant-cell myocarditis
Keywords : autopsy, giant cell myocarditis, sudden cardiac death