Pulmoner Langerhans Hücreli Histiyositozisli İki Olgu ve Literatür Derlemesi

Authors : Esra YAZAR, Selim KAHRAMAN, Akif ÖZGÜL, Nur BÜYÜKPINARBAŞI, Veysel YILMAZ

Pages : 208-211

View : 26 | Download : 10

Publication Date : 2013-12-01

Article Type : Other Papers

Abstract :The etiology and frequency of pulmonary langerhans’cell histiocytosis PLCH is not exactly known and it is a rare pulmonary parenchymal disease. We investigated two cases first case aged 19 yr male, second case aged 22 yr male which we have diagnosed in our clinic. Both of the patients were smoker as evidence implicating tabacco smoke in the etiology 8p/year and 30p/year, respectively . The presentation symptom in the first case was dyspnea and in the other case was constitutional symptoms and hemoptysis. The DLCO was low in both cases. Whereas in the first case a restrictive pattern of pulmonary function disorder was observed in the second case there was an obstructive pattern with incrased lung volumes. Appearence of the thorax computed tomography of both patients was consistent with PLCH. The diagnosis was made by immunohistochemical staining of transbronchial biopsy and by high CD-1a positive langerhans’ cell ratio 5% in bronchoalveolar lavage in the first and second case, respectively. The diagnosis of both patients was made with less invasive procedure due to the typically radiologic findings and age. An open lung biopsy is not necessary in patients with typically clinic and radiologic findings
Keywords : pulmonary langerhanscell histiocytosis, radiologic manifestation, diagnosis