The Effect of Copd Presence, Quality of Life and Nutritional Status on Short-Term Survival in Patients With Non-Small Cell Lung Cancer

Authors : Murat YILDIZ, Sema AVCI, Oral MENTEŞ, Meriç ÜNVER, Deniz ÇELİK, Pınar AKIN KABALAK, Ülkü YILMAZ

Pages : 596-603

Doi:10.31067/acusaglik.850937

View : 27 | Download : 10

Publication Date : 2021-07-01

Article Type : Research Paper

Abstract :Objectives: The aim of this study is to evaluate the association of survival with nutritional status, comorbidity and life quality of patients with locally advanced and advanced non-small cell lung cancer insert ignore into journalissuearticles values(NSCLC); coexisting with chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD);. Patients and methods: This study was performed with 64 patients insert ignore into journalissuearticles values(6 female, 58 male); diagnosed with locally advanced and advanced NSCLC from March to August 2015. Demographic features of the patients were evaluated with Mini Nutritional Test insert ignore into journalissuearticles values(MNT);, Charlson Comorbidity Index insert ignore into journalissuearticles values(CCI);, Fat Free Mass Index insert ignore into journalissuearticles values(FFMI);, Nutritional risk screening insert ignore into journalissuearticles values(NRS 2002);, European Organization for Research and Treatment of Cancer insert ignore into journalissuearticles values(EORTC);, Quality of Life insert ignore into journalissuearticles values(QOL); Group insert ignore into journalissuearticles values(EORTC-QLQ-C30);. The association of those scales’ results with survival was analyzed. Results: Of the patients, 34.4% insert ignore into journalissuearticles values(n=22); had the diagnosis of COPD. A significant relation between the presence of COPD and survival was not detected. According to NRS 2002, 33% of the patients were under the risk of nutritional deficiency. According to MNT, 18.8% of the patients showed presence of malnutrition. According to CCI, the patients were in low, moderate and high-risk groups respectively 57.8%,37.5% and 4.7%. FFMI average of the survivors and ex ones were 19.74 kg/m2 and 18.10 kg/m2, respectively. After 6 month-follow up, 25% of the patients died. In the univariate analyses, MNT insert ignore into journalissuearticles values(p=0.000);, NRS 2002 insert ignore into journalissuearticles values(p=0.000); and FFMI insert ignore into journalissuearticles values(p=0.012); were associated with survival. According to EORTC-QLQ-C30 scale, performance status, functional scale, physical, occupational, social function values and symptom scores were associated with survival. Conclusion: In the study when nutritional status were evaluated with FFMI and life quality scales, the result was detected to be associated with survival. On the other hand, whether or not the patient was diagnosed with COPD, histological type of the cancer, stage of the disease, metastasis sites and CCI were not detected to be associated with survival.
Keywords : non small cell lung cancer, chronic obstructive pulmonary disease, survival