The Effect of Hashimoto's Thyroiditis on the Development of Thyroid Carcinoma

Authors : Sezin Doğan Çakır, Özlem Çelik, Özer Açbay

Pages : 152-158

Doi:10.31067/acusaglik.1394223

View : 106 | Download : 106

Publication Date : 2024-04-01

Article Type : Research Paper

Abstract :Background/Purpose: Our aim was to investigate whether Hashimoto’s Thyroiditis (HT) effects the development of thyroid carcinoma or not. Methods: We examined 772 patients’ file between january 2000 and december 2010 retrospectively at Istanbul University Cerrahpasa Medical School Endocrinology and Metabolism Clinic, whom fine-needle aspiration biopsy (FNAB) were applied. We noted patient’s demographic findings, anti-thyroglobulin antibody (anti-TG) and anti-thyroperoxidase antibody (anti-TPO) levels, ultrasonography (US) and cytology reports. We compared findings of HT patients with nonhashimoto control group. Results: 393 patients with mean age 46.11 ± 12.53 of whom 39 male and 354 female with HT and thyroid nodules (HT group) were compared with 379 patients with mean age 47.5 ± 12.6 of whom 53 male and 326 female with nonautoimmune thyroid disease and nodules (control group). We found the prevalance of differentiated thyroid carcinoma 6.6% in the HT group and backwards 12.9% in the control group (p=0.03). There were not any distinguishing US findings between groups. Anti-TPO positivity was significantly higher in benign nodules (p=0.008). Conclusion: Our findings did not point out an increased risk of Hashimoto’s nodules in terms of differentiated thyroid carcinoma development.
Keywords : Hashimoto\'s Thyroiditis, thyroid carcinoma, thyroid nodules, fine needle aspiration biopsy