The Effect of Novel Boron Ester Derivatives on Wound Healing

Authors : Arzu Özcan İlçe, Ümmühan Yiğit, Eylem Suveren, Cevher Altuğ, Çetin Boran, Serap Kolukısa, Muhammet Büyükbayram

Pages : 33-46

View : 26 | Download : 30

Publication Date : 2024-12-05

Article Type : Research Paper

Abstract :Boron\\\'s unique physical and chemical characteristics make it possible to create novel boron-containing molecules resulting in a wide range of distinct biological properties. This paves the way for exciting prospects in various scientific disciplines and medical applications through advanced molecular design and research. In this study, two novel boron-containing molecules were synthesized and their effect on wound healing property were tested in a pilot study as phase 0, in vivo and in vitro in order to test them on a larger sample. The wound healing percentage of molecule 1 was higher than that of all other groups in terms of wound healing percentage (p = 0.001), and it did not lead to a chronic subcutaneous inflammatory reaction (p<0.05). Collagen production of molecule 1 and molecule 2 on day 7 (p<0.05) and that of molecule 2 on day 14 (p>0.05) were higher. In this study, obtained boron containing compounds show promising effect on wound healing macroscopically (wound healing percentage) and microscopically (microbiological, histopathological, and immunohistochemical). As a result of the study, 2 patent applications were made.
Keywords : Yara iyileşmesi, yara bakımı, bor