Investigation of Serum Zinc Level in Non-Diabetic, Pre-Diabetic And Diabetic Patients: A Prospective Cross-Sectional Study

Authors : Ece Yiğit

Pages : 19-23

Doi:10.61845/agrimedical.1400162

View : 57 | Download : 75

Publication Date : 2024-02-29

Article Type : Research Paper

Abstract :Aim: The aim of the study was to determine the serum zinc level in non-diabetic, pre-diabetic and diabetic patients and reveal the relationship between serum zinc level and glycemic status. Material and Method: The study was a single-center, prospective, cross-sectional study. Fasting blood sugar, glycated hemoglobin, insulin resistance, and serum zinc levels of patients admitted to the internal medicine outpatient clinic were measured. Patients were categorized as non-diabetic, pre-diabetic, and diabetic according to their results, and compared regarding serum zinc levels. Results: Zinc was significantly lower in the diabetes group than in the other groups (p<0.001), while there was no significant difference between non-diabetes and prediabetes groups. Zinc was negatively correlated with fasting blood sugar (r=-0.342, p<0.001), HOMA-IR (r=-0.344, p<0.001), and HbA1c (r=-0.327, p<0.001). Zinc had a sensitivity of 65.0%, specificity of 59.5%, accuracy of 61.3%, positive predictive value of 44.5%, and negative predictive value of 77.3% to predict diabetes for the cut-off point of 73 (AUC: 0.654, 95% CI: 0.588-0.720, p<0.001). In addition, multivariable logistic regression analysis revealed that low zinc (<73) was independently associated with the diabetes after adjusted by age and gender (OR: 2.618, 95% CI: 1.571-4.365, p<0.001). Conclusion: While serum zinc levels were at similar levels in non-diabetic and prediabetic patients, they were significantly lower in diabetic patients, indicating that zinc levels decreased as glycemic control worsens. Measuring the serum zinc level in the risk group and replacing it if deficient may help prevent the development of diabetes by supporting glycemic control and reducing oxidative stress.
Keywords : Diabetes mellitus, çinko, insülin, eser elementler