Evaluation of Antimicrobial Effect against Some Microorganisms and Apoptotic Activity against Candida Species of New Vanillin Derivatives

Authors : Hakan ÜNVER, Zerrin CANTÜRK, M. Güçlü ÖZARDA

Pages : 87-94

Doi:10.18466/cbayarfbe.475456

View : 18 | Download : 8

Publication Date : 2019-03-22

Article Type : Research Paper

Abstract :Eleven vanillin derivatives was synthesized, characterized successfully and their antibacterial and anticandidal properties were investigated on seven bacterial species and four candida species. These bacterial species are Staphylococcus aureus , Enterococcus faecalis , Listeria monocytogenes , Klebsiella pneumoniae , Pseudomonas aeruginosa , Escherichia coli , and Bacillus subtilis and candidal species are Candida albicans, Candida glabrata, Candida krusei and Candida parapsilosis . Most of the synthesized compounds were showed good activity against studied microorganisms compared with Chloramphenicol. Compounds 2c, 2d and 2k were exhibited remarkable antibacterial activities especially on Escherichia coli . In addition, Klebsiella pneumoniae , Pseudomonas aeruginosa and Bacillus subtilis were found to be the most susceptible species amongst the investigated microorganisms
Keywords : Antimicrobial, Vanillin, Schiff base