Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

Authors : Nadir Bilgin Akgül, Muhammed Mehdi Üremiş, Nuray Üremiş, Ebru Annaç, Rıfat Cesur Bozat, Murat Koca, Ahmet Özkaya, Elif Merve Betül Yanılmaz

Pages : 1-9

Doi:10.30569/adiyamansaglik.1373918

View : 100 | Download : 108

Publication Date : 2024-04-23

Article Type : Research Paper

Abstract :Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA). Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPA+CM. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), and Malondialdehyde (MDA) levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.
Keywords : Bisfenol A, Kumarin, Böbrek, Antioksidan, Oksidatif stres