Evaluation of the effect of a natural monoterpenic phenol on the cytotoxicity of carfilzomib

Authors : Ayşe Erdoğan

Pages : 189-199

Doi:10.30569/adiyamansaglik.1522904

View : 63 | Download : 37

Publication Date : 2024-12-31

Article Type : Research Paper

Abstract :Aim: The aim of this study was to reveal whether carfilzomib, proteasome inhibitor, and carvacrol, a natural monoterpenic phenol, causes cytotoxic and apoptotic effects and oxidative stress on A-549 cells. Materials and Methods: Lactate dehydrogenase (LDH) activity test was used. Changes in caspase 3 and glutathione peroxidase enzyme activities in cells were determined. Results: It was determined that carfilzomib alone and together with carvacrol caused a raise in the activities of lactate dehydrogenase (LDH), glutathione peroxidase and apoptotic enzyme, caspase-3 activity, compared to the control. Conclusion: Our study showing that carfilzomib alone and together with carvacrol gave different responses may be guiding in determining new strategies to be applied in lung cancer treatment.
Keywords : Akciğer kanseri, Karvakrol, Carfilzomib, Apoptotik etki