Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Authors : Dursun AYGUN, Cetin Kursad AKPİNAR, Serpil YON, Musa Kazım ONAR

Pages : 225-231

Doi:10.5798/dicletip.338976

View : 12 | Download : 5

Publication Date : 2017-09-20

Article Type : Research Paper

Abstract :Normal 0 21 false false false TR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} O b j e c ti v e : P a r k i n s o n ’ s di s e as e ( PD) is a c hr o n ic p r og ress ive n e u r o d e g en er a ti v e d i s o r d e r c h a r ac t e r i z e d b y t r e mo r , r igid i ty, br a dy k i ne s i a , a n d p ost u r a l i n s t a b i l ity. PD als o i n vo l v e s n o n m o tor m a n i f e s t a tio n s s u c h a s a ut o n omic f a i l ur e , c og n iti v e disor d e r s , a n d sle e p diso r d e r s . Th e s e cl i n i ca l c h a r ac t er is t i c s a r e n ot id e n tic a l in s e v er i ty, f r eq u en c y , a n d o n s e t ti m e i n al l PD p a t i en ts. W e ass e sse d w h e t h e r t h e r e is a n e g a tive e f f e c t o n c og n iti o n of cl i n i ca l a uto n omic dy s fu n c ti o n i n PD p a t i e n ts. M e thod s : This p r osp e c ti v e s tudy i n cl ud e s 3 7 PD p a ti e n t s w i th a uto n omic f a i l u r e . Fr om e ac h p a t i e n t, a q u e s ti o n n a i r e ( SCOP A-A UT) i n cl ud i n g   s y mp t oms   ass o c i a t e d   w ith   cl i n i ca l   a uto n omic   dy s fu n c t i on s u c h   a s   c o n s ti p a t i o n ,   u r i n a r y i n c o n t i n en c e , o r tho s t a tic h y po t e n s i o n , a n d h y p e r h y d r o s is was o b t a i n e d a n d t h e p a t i en t ’ s cl i n i ca l c o n dit i on was r a t e d on t h e H o e hn a n d Y a h r ( H - Y ) scal e in t h e O N - m e dic a t i on s t a t e . T h e p a t i en t s ’ c og n i tive f u n c ti o n was ass e ss e d b y t h e M i n i-Me n t a l State Ex a m i n a t i on (MM SE ) , B l e s s e d sc o r e , F r o n t a l Ass e ss m e n t B a tt e r y ( FA B ) , a n d Digid S p a n T e s t ( DS T ) ( fo r wa r d, re v er s e ) . Co g n iti v e t e s t sc o r e s we r e c o m p a r e d w i th SC O P A - OUT sc o re s . R e s u l ts: M e a n a ge was 66 , 5±11.2 y e a r s . T h e r e was n o c o r r e la tion b e t we e n c o g n itive t e s t sc o re s an d SC OP A - OUT sc o re s   ( p>0.05).   H o w e v e r ,   H - Y   sc o re s   w e r e   n e g a ti v e l y c o r re la t e d   w i th   the   D S T f ,   D S T r ,   FA B,   a n d   MM SE   s c o re s ( p50.005, r :- 0.451; p50. 0 25, r : - 0.367; p50.0 4 0, r : - 0.340; p50.044, r 5- 0.3 3 3, r e s p e c ti v e l y ) . Co n cl u s io n s : Acc o r d i n g to o ur r e s u l ts, cl i n i ca l a ut o n om i c dy s fu n c ti o n did n ot se e m to ha ve a n e f f e c t on c o g n it i o n . I n a ddi t io n , s e v e r ity o f c o g n iti v e dy s f u n c ti o n s h o w e d a s t r o n g ne g a ti v e c o r r e la tion w i th the s t a g e o f di s e as e .
Keywords : Blessed score, Clinical autonomic dysfunction, Cognitive test, Parkinsons disease