Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Authors : Muhammet Hulusi SATİLMİSOGLU, Mehmet GUL, Huseyin Altug CAKMAK, Nilgun ISİKSACAN, Selahattin TUREN, Ugur KOKTURK, Emre YİLMAZ, Muammer KARAKAYALI, Aydin Rodi TOSU

Pages : 369-377

Doi:10.5798/dicletip.497879

View : 17 | Download : 8

Publication Date : 2018-12-13

Article Type : Research Paper

Abstract :Objective: Vitamin-D status is very important for optimal function of human body especially cardiovascular system. The aim of this study was to investigate the long term prognostic value of admission vitamin D level in acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Methods: One hundred fifty seven consecutive patients, who were admitted to a training and research hospital with a diagnosis of STEMI and underwent PPCI, were recruited in this prospective study. The study patients were divided into 2 groups according to their vitamin-D levels as follows: High vitamin-D group (n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease (CAD) was assessed with calculation of the SYNTAX score. Results: There were significant negative correlations between Vitamin-D level and SYNTAX score, serum glucose, and gender, but a positive correlation with hemoglobin level. Cardiovascular mortality was found to be significantly higher in the low vitamin-D group as compared to the high group (p<0.001). In multivariate analysis, low vitamin-D level was found as a significant independent predictor of long term cardiovascular mortality after adjusting for other risk factors. Conclusion: We demonstrated that low admission vitamin-D is related to severity of CAD. Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI.
Keywords : Vitamin D, Mortality, SYNTAX score