The Effect of Neutrophil to Lymphocyte and Neutrophil to Platelet Ratios on Prognosis in Stroke Patients

Authors : Pınar Bengi BOZ, Murat BOZ, Dilek ACAR, Zeynep Selcan ŞANLI, Ahmet EVLİCE, Semih GİRAY

Pages : 558-564

Doi:10.5798/dicletip.1220732

View : 15 | Download : 5

Publication Date : 2022-12-19

Article Type : Research Paper

Abstract :Background: The aim of this study is to determine the correlation of neuroinflammatory response biomarkers neutrophil to lymphocyte ratio insert ignore into journalissuearticles values(NLR);, neutrophil to platelet ratio insert ignore into journalissuearticles values(NPR); with risk factors, etiology, and prognosis in stroke patients. Methods: Cases diagnosed with ischemic stroke were recruited in this study. Demographic data, comorbidities, laboratory findings, carotid doppler ultrasonography, NIHSS insert ignore into journalissuearticles values(National Institutes of Health Stroke Scale); and MRS insert ignore into journalissuearticles values(modified rankin scale); scores of the cases were documented. Afterwards, the cases were divided into 3 groups insert ignore into journalissuearticles values(posterior circulation infarct, anterior circulation infarct, and lacunar infarct);. Results: A total of 133 patients, 65 female and 68 males, aged between 24 and 94 were included in this study. At the end of hospitalization, NLR insert ignore into journalissuearticles values(p=0.001); and NPR insert ignore into journalissuearticles values(p=0.007); were significantly found high in patients with unfavorable functional outcome insert ignore into journalissuearticles values(MRS≥3); and those who died compared to NLR insert ignore into journalissuearticles values(p=0.001); and NPR insert ignore into journalissuearticles values(p=0.008); in the favorable functional outcome group. The NLR cut-off value for unfavorable functional outcome insert ignore into journalissuearticles values(95% confidence interval lower limit of area-under-curve of ROC≥0.7); was found to be 4.0. Conclusion: High NLR and NPR values measured at first admission in patients with acute ischemic stroke are highly associated with unfavorable functional outcome and mortality, and NLR and NPR are important prognostic biomarkers in patients with acute ischemic stroke.
Keywords : Ischemic stroke, NLR, NPR, arterial thrombosis and embolism