Brain Metastases, Large Cell Neuroendocrine Carcinomas and Prognosis

Authors : Engin KUT, Serkan MENEKŞE

Pages : 30-36

Doi:10.5798/dicletip.1266706

View : 8 | Download : 7

Publication Date : 2023-03-19

Article Type : Research Paper

Abstract :Objective: Pulmonary large cell neuroendocrine carcinomas insert ignore into journalissuearticles values(LNECs); are not common but brain metastases are common in LNEC patients. Because of their rarity, there are no randomized controlled trials on optimal treatment. Generally available data are based on case reports and retrospective studies. For this reason, we retrospectively analyzed patients with LNEC that we followed up for brain metastases to contribute to the literature. Methods: Between 2009 and 2020, 38 patients with brain metastases diagnosed with LNEC in our center were reviewed retrospectively. Results: 38 patients were evaluated. The mean survival time was 5.17 months insert ignore into journalissuearticles values(95% confidence interval insert ignore into journalissuearticles values(CI); : 3.17-7.13);. In multivariate analysis showed us that; shorter overal survival is associated with age insert ignore into journalissuearticles values(p=0.001);, uncontrol of primary cancer insert ignore into journalissuearticles values(p=0.014);, presence of metachronous metastases insert ignore into journalissuearticles values(p=0.003);, poor Eastern Cooperative Oncology Group insert ignore into journalissuearticles values(ECOG); performance score insert ignore into journalissuearticles values(p=0.025);, and high uric acid level insert ignore into journalissuearticles values(p=0.001); and high lactate dehydrogenase insert ignore into journalissuearticles values(LDH); levels insert ignore into journalissuearticles values(p=0.009);. Conclusion: LNECs are rare but aggressive cancers. LNECs often metastasize to the brain. According to our study, high LDH, high uric acid, poor ECOG performance score, ≥65 years, metachronous metastasis, uncontrolled primary tumor are associated poor prognosis. LDH, uric acid, age, presence of metachron metastasis, controbility of primary tumor can be used as easy and inexpensive biomarkers to determine the prognosis and in the follow-up and treatment of patients with LNECs with brain metastases as metastases seen of other cancers.
Keywords : Brain metastasis, prognosis, lung cancer, large cell neuroendocrine carcinomas