Evaluation of infections developing during autologous hematopoietic stem cell transplantation in AML patients

Authors : Selda KAHRAMAN

Pages : 377-384

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Publication Date : 2021-12-30

Article Type : Research Paper

Abstract :Infections are the leading treatment-related cause of mortality and morbidity associated with high dose therapy with autologous hematopoietic stem cell support (HSCT). The aim of the study is to evaluate the data of 47 patients with AML who developed infections in association with autologous HSCT in Izmir Medicalpark Hospital between November 2012 and April 2018. Materials and Methods: This study is a retrospective evaluation of the data from 47 patients with AML who developed infections in association with autologous HSCT. All infection episodes were noted, beginning from the neutropenia period until the development of neutrophil engraftment. Results: 24 patients were female and 23 patients were male. The median age at the occurrence of the condition was 39 years (range:18-68). Neutrophil engraftment occurred at an average of 11 days after the transplantation, platelet engraftment occurred at an average of 21 days. In 41 (87.2%) patients neutropenic fever occurred during transplantation. The cause of fever remained unknown in 20% of the patients, 70% of the patients had a microbiologically documented infection and 10% of the patients had only clinically documented infection. 19 patients had a catheter related infections, 7 patients had pneumonia, 8 patients had urinary tract infection and 3 patients had possible invasive pulmonary aspergillosis. Conclusion: In our department, infections do not present a significant risk for mortality in autologous HSCT among patients with AML. Early detection of the causative agent of the infection is of crucial importance for an optimal treatment and prognosis. Keywords: AML, autologous stem cell transplantation, infection
Keywords : AML, autologous stem cell transplantation, infection