The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson`s Disease

Authors : Ayşe Nur YILDIRIM, Ferhat ŞİRİNYILDIZ, Recep ÖZMERDİVENLİ

Pages : 179-184

Doi:10.18678/dtfd.1301252

View : 41 | Download : 62

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide insert ignore into journalissuearticles values(VIP);, which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP insert ignore into journalissuearticles values(25 ng/kg); to the RT+VIP group, and rotenone and naringenin insert ignore into journalissuearticles values(10 mg/kg); to the RT+NG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinson\`s model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RT+NG insert ignore into journalissuearticles values(p=0.023);, malondialdehyde insert ignore into journalissuearticles values(MDA); levels both in the RT+VIP insert ignore into journalissuearticles values(p=0.039); and RT+NG insert ignore into journalissuearticles values(p=0.032);, and superoxide dismutase insert ignore into journalissuearticles values(SOD); inhibition in the RT+VIP insert ignore into journalissuearticles values(p=0.042); groups decreased significantly, the 8-OHdG levels in the RT+VIP insert ignore into journalissuearticles values(p=0.042); and RT+NG insert ignore into journalissuearticles values(p=0.034); groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinson\`s disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinson\`s disease.
Keywords : Parkinson hastalığı, rotenon, sıçanlar, vazointestinal peptit