Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Authors : Oruc Sahin, Emine Hande Kılıçaslan Şahin, Ersel Dağ

Pages : 56-63

Doi:10.18678/dtfd.1381925

View : 55 | Download : 74

Publication Date : 2024-04-30

Article Type : Research Paper

Abstract :Aim: This study aimed to review cognitive function and fine motor skills in patients with multiple sclerosis (MS) and investigate the association with magnetic resonance imaging (MRI) results. Material and Methods: The study included 22 patients diagnosed with relapsing-remitting MS and 22 controls. Participants underwent neuropsychological tests, including the Stroop test, Rey auditory verbal learning test (RAVLT), line bisection test (LBT), serial reaction time test (SRTT), and finger tapping test (FTT). The relationship between severity of disease, MRI, and test performance was investigated. Results: It was determined that the patients were lateralized to the right in the LBT data, while the control group was lateralized to the left (p=0.024). On cognitive tests, there was no significant difference in Stroop test results (p=0.134), but the mean overall RAVLT of the patient group was significantly lower than that of the control group (p<0.001). Patients had significantly longer reaction times in SRTT (p=0.038). A positive correlation was found between the expanded disability status scale (EDSS) score and LBT results (r=0.326, p=0.031), and a negative correlation between RAVLT results and EDSS score. For fine motor skills, a negative correlation was observed between FTT results and the number of MS plaques in the left hemisphere (r=-0.431, p=0.045), and a positive correlation between the number of SRTT error and the number of plaques in the juxtacortical regions (r=0.461, p=0.031). Conclusion: This study shows that the impairment of cognitive functions in MS disease is associated with both the course and severity of the disease and MRI findings.
Keywords : Multipl Skleroz, Bilişsel İşlevler, Nöroanatomik Lokalizasyon, İnce Motor Beceri