Potential Use of Breadfruit (Artocarpus altilis) Leaf Extract to Recover Hepatic and Renal Damage in Alloxan-Induced Diabetic Rats

Authors : Hesty SETİAWATİ, Yulia Yusrini DJABİR, Hardi HARDİ, Subehan LALLO, Muhammad Husni CANGARA

Pages : 151-160

Doi:10.55262/fabadeczacilik.1134528

View : 25 | Download : 8

Publication Date : 2022-08-01

Article Type : Research Paper

Abstract :The antihyperglycemic effect of breadfruit leaf (Artocarpus altilis) extract has been demonstrated in a preclinical study using an alloxaninduced diabetic model. This study aimed to examine whether breadfruit leaf extract also ameliorated liver and kidney injury in alloxan-induced diabetic rats. Male Wistar rats (n=35) were used in the study. All other animals except control group (group I, n=5) were injected with alloxan (155 mg/kg body weight). After 3 days, the hyperglycemic rats with blood glucose >200 mg/dl were divided into 4 treatment groups: placebo (alloxan group), Breadfruit Leaf (BL) extract 100 mg/kg, BL extract 200 mg/kg, and BL extract 400 mg/kg. Treatments were administered daily for 14 days, and blood samples were drawn at baseline, after alloxan injection, and following treatments to obtain serum glutamic pyruvic transaminase (SGPT) and creatinine levels. Alloxan was found to cause a significant increase in rat blood glucose, SGPT, and creatinine levels three days post alloxan injection (P<0.01). After treatment, rats that received 200 mg/kg and 400 mg/kg BL extracts had significantly lower SGPT levels compared to those treated with placebo alone (P<0.05). Liver histological damage was also significantly alleviated, especially with the 400 mg/kg dose of BL extract. Although serum creatinine level was restored, alloxan-induced tubular degeneration in renal tissue was still evident. In conclusion, BL extract at a dose of 400 mg/ kg improved alloxan-induced liver dysfunction and tissue damage but was less effective at alleviating kidney damage. This result may support the use of breadfruit leaf extract as herbal drug with a hepatoprotective effect.
Keywords : Breadfruit leaf, Artocarpus altilis, diabetic rats, alloxan, liver damage, kidney damage