Determination of Antioxidant Activity of Salvia sclarea L. and Its Inhibitory Effects on Acetylcholinesterase and Monoamine Oxidase A

Authors : Yasemin Yücel YÜCEL, Ebru ÖZDEMİR

Pages : 255-264

Doi:10.55262/fabadeczacilik.1293118

View : 36 | Download : 24

Publication Date : 2023-08-01

Article Type : Research Paper

Abstract :Over the past two to three decades, there has been a significant increase in research focused on the treatment of neurodegenerative disorders. In this study, our aim was to determine some biological activities of the ethanolic and methanolic extracts of Salvia sclarea L. The extracts were first assessed for their capacity to scavenge DPPH radicals, then their total phenolic content insert ignore into journalissuearticles values(TPC); were determined. Afterward, the extracts were evaluated for their effects on acetylcholinesterase insert ignore into journalissuearticles values(AChE); and monoamine oxidase-A insert ignore into journalissuearticles values(MAO-A);. These two enzymes play a crucial role in the treatment of neurodegenerative disorders. It has been found that, the DPPH activity of the methanolic extract was higher than that of ethanolic extracts; while TPC was higher for the ethanolic extract. For AChE, the IC50 values for ethanolic extract and methanolic extract were 0,27±0,005 mg/mL and 1,19±0,037 mg/mL, respectively. And for MAO-A, the IC50 values for ethanolic extract and methanolic extract were 6,53±0,72 mg/mL and 3,03±0,05 mg/mL, respectively. As the result of this study, the antioxidant property of Salvia sclarea was determined, and it was observed that this property changed in accordance with the total phenolic content of the plant. It has been shown that the extracts have inhibitory effects on both enzymes. This means, the obtained data are promising for further drug development studies.
Keywords : Salvia sclarea L, DPPH, total fenolik içerik, asetilkolinesteraz, monoamin oksidaz A, nörodejeneratif bozukluklar