Dipyridamole cocrystal tablets with enhanced solubility and dissolution at intestinal pH

Authors : Monika Nijhawan, Sadhana Dhyagala, Sailaja Gunnam, Rajeswari Aleti, Dr Trapti Saxena

Pages : 37-50

Doi:10.55262/fabadeczacilik.1318448

View : 35 | Download : 68

Publication Date : 2024-03-26

Article Type : Research Paper

Abstract :The aim of the study was to prepare dipyridamole(DPM) cocrystals to alter itsphysicochemical properties as it ispoorly soluble in water, 6.8 pHbuffer and belongs to BCS class II. Cocrystals were prepared usingneat grinding method. Initial screening of cocrystals was done with melting point determination indicating formation of nine cocrystals. Based upon interference studies nine cocrystalswere finalized for solubility and dissolution studies. DPM-citric acid, DPM-hippuric acid, DPM-tartaric acid and DPM-oxalic acid cocrystalsshowed the significant enhancement in solubility and dissolution in 6.8 pH buffer.Further confirmation was done by DSC and PXRD studies. DPM-hippuric acid cocrystalshave shownpromising results for formation of cocrystals and considered for tablet formulation. DPM-hippuric acid cocrystal tablets were prepared by using various levels of carboxymethyl cellulose and microcrystalline cellulose. These tablets showed acceptable physical characteristics with subsequent rapid dissolution.
Keywords : Dipyridamole DPM, Cocrystals, Neatgrinding, DSC, Solubility, Dissolution