Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients with Extrahepatic Cholestasis: A Retrospective Cohort Study

Authors : Beyza YÜKSEL, Nihat OKÇU

Pages : 32-40

Doi:10.46332/aemj.1017662

View : 13 | Download : 5

Publication Date : 2023-04-16

Article Type : Research Paper

Abstract :Purpose: Differential diagnosis of extrahepatic cholestasis can be challenging due to the variable sensitivity and specificity rates of imaging techniques. Magnetic resonance cholangiopancreatography insert ignore into journalissuearticles values(MRCP); is a non-invasive method used for the evaluation of biliary tree. We aimed to investigate the diagnostic accuracy of MRCP in biliary obstruction. Materials and Methods: Medical records of patients admitted with extrahepatic cholestasis between January 2012 and December 2016 were retrospectively reviewed. Patients who had endoscopic retrograde cholangiopancreatography insert ignore into journalissuearticles values(ERCP); following MRCP were included. The final diagnosis of ERCP was accepted as gold standard. The diagnostic efficiency of MRCP was evaluated by calculating sensitivity, specificity, accuracy, negative and positive predictive values as compared with ERCP. Results: There were 615 patients with a mean age of 60.1±17.5 years. Using MRCP, choledocholithiasis, malignant and benign strictures were diagnosed in 337insert ignore into journalissuearticles values(54.8%);, 101insert ignore into journalissuearticles values(16.4%);, and 39 patients insert ignore into journalissuearticles values(6.3%);, respectively. Normal MRCP findings were present in 65 patients insert ignore into journalissuearticles values(10.6%);. Final diagnoses via ERCP were: choledocholithiasis insert ignore into journalissuearticles values(n=390, 63.4%);, malignant stricture insert ignore into journalissuearticles values(n=152, 24.7%);, benign stricture insert ignore into journalissuearticles values(n=62, 10.1%);, and normal findings insert ignore into journalissuearticles values(n=11, 1.8%);. The sensitivity and specificity of MRCP were 70.8% and 72.9% for choledocholithiasis, 55.9% and 96.5% for malign stricture, 16.1% and 94.8% for benign stricture, respectively. Overall accuracy rates were 71.5%, 86.5%, and 86.8% for choledocholithiasis, malign and benign strictures, respectively. Conclusion: Diagnostic accuracy of MRCP is variable for different biliary/cholestatic etiologies. Due to a lower sensitivity for chole docholithiasis, normal MRCP findings should be handled with caution, especially when there is a clinical suspicion of biliary obstruction.
Keywords : sensitivite, spesifite, ERCP, kolestaz, MRCP