Evaluation of the Triglyceride Glucose Index as a Marker of Insulin Resistance in Adults with Isolated Impaired Glucose Tolerance

Authors : Gül KIRTIL, Medine ALPDEMİR, Mehmet Fatih ALPDEMİR, Mehmet ŞENEŞ

Pages : 205-211

Doi:10.46332/aemj.1140228

View : 50 | Download : 98

Publication Date : 2023-08-07

Article Type : Research Paper

Abstract :Purpose: By analyzing long-term laboratory data, we aim to evaluate the relationship between the TyG and Homeostatic Model Assessment for Insulin Resistance insert ignore into journalissuearticles values(HOMA-IR); in the adult population with isolated impaired fasting glucose insert ignore into journalissuearticles values(IFG);, and also to determine the cut off value of The triglyceride insert ignore into journalissuearticles values(TG); to glucose index insert ignore into journalissuearticles values(TyG); to estimate the IR in our population. Materials and Methods: In this study, data were evaluated retrospectively from medical records. Fasting glucose, lipid panel [Total cholesterol, TG, High-density lipoprotein insert ignore into journalissuearticles values(HDL);, Low-density lipoprotein insert ignore into journalissuearticles values(LDL);] and insulin levels were analyzed with commercially reagents. insert ignore into journalissuearticles values(Roche Cobas C701, Roche Diagnostic, Germany);. High-Performance Liquid Chromatography insert ignore into journalissuearticles values(HPLC); method was used for hemoglobin A1c insert ignore into journalissuearticles values(HbA1c); insert ignore into journalissuearticles values(Lifotronic H9, Lifotrophic Technology, China);. TyG, HOMA-IR, and TG/HDLcholesterol were calculated. IR was defined as HOMA-IR ≥2.5. Results: A total of 440 subject, insert ignore into journalissuearticles values(controls: 230 and IFG:210);, were included in our study. The average age of the subjects was 42.5±12.0 years and 44.7±10.7 years for IFG and control, respectively. Glucose, total cholesterol, TG, LDL-cholesterol, insulin, HbA1c, TG/HDL-cholesterol, HOMA-IR, and TyG were significantly higher in the IFG group insert ignore into journalissuearticles values(p<0.001);. There was a weak but significant correlation between HOMA-IR and the TyG insert ignore into journalissuearticles values(r=0.210, p=0.009);. In the ROC analysis, the AUC for HOMA-IR and the TyG, respectively was 0.867 insert ignore into journalissuearticles values(95% CI, 0.833-0.900, p<0.001); and 0.708 insert ignore into journalissuearticles values(95% CI, 0.659-0.758, p<0.001);. Conclusions: In our study, the TyG is proposed as a relatively accurate, simple, easily accessible, and low-cost marker for IR evaluation with IFG patients. However, population-based studies with higher patient participation are needed for future studies.
Keywords : HOMA IR, İnsülin direnci, TG HDL C, TyG indeksi, Bozulmuş açlık glukozu, Bozulmuş glukoz toleransı