Protective Effects of Rosuvastatin on Kidney in Experimental Hypertension Rats Models

Authors : Elif ONAT, Ahmet TÜRK, Nevin KOCAMAN

Pages : 231-237

Doi:10.46332/aemj.1222769

View : 67 | Download : 102

Publication Date : 2023-08-07

Article Type : Research Paper

Abstract :Purpose: Hypertension is responsible for approximately 30% of patients who reach end-stage renal disease. Statin is known to reduce the risk of developing kidney disease. In this study, the changes in caspase-3 and fibrillin1 in the kidney tissue of rats with hypertension using L-NAME were investigated along with how rosuvastatin affected the changes caused by hypertension on these proteins. Materials and Methods: 18 Wistar Albino male rats weighing 200-220 g were used in the study. The rats were divided into 3 groups with 6 animals in each group insert ignore into journalissuearticles values(1.Control, 2.Hypertension, 3.Rosuvastatin);.To induce hypertension, rats were given L-NAME for 7 weeks. After the second week, rosuvastatin was given by oral gavage for 5 weeks. Blood pressure values were evaluated on days 0, 14, 28, 42. At the end of the experiment, all rats were sacrificed and caspase-3 and fibrillin1 levels were evaluated. Results: Blood pressures were found to be higher in the hypertension group on the 14th, 28th, and 42nd days insert ignore into journalissuearticles values(p=0.001);. Rosuvastatin caused a decrease that was found to be insignificant at 28th, 42nd days. Caspase-3 insert ignore into journalissuearticles values(p=0.001);, fibrillin1 insert ignore into journalissuearticles values(p=0.001); immunoreactivity were found to be increased in the hypertension group. Compared with the hypertension group, caspase-3 insert ignore into journalissuearticles values(p=0.031);, fibrillin1 insert ignore into journalissuearticles values(p=0.030); immunoreactivity were decreased in the rosuvastatin group. However, caspase-3 insert ignore into journalissuearticles values(p=0.036); and fibrillin1 insert ignore into journalissuearticles values(p=0.041); immunoreactivity was increased in the rosuvastatin group compared to the control group. Conclusion: Although rosuvastatin didn’t significantly decrease blood pressure, it is thought that caspase-3 and fibrillin1 may mediate its protective effect on hypertensive kidneys.
Keywords : Statin, Kaspaz 3, Fibrilin 1, L NAME