The Acute Effect of Chlorpromazine on Body Temperature in Intensive Care Unit Patients

Authors : Ömür İLBAN, Muhammed Emin ZORA, Bülent Devrim AKÇAY, Jale Bengi ÇELİK, Faruk ÇİÇEKCİ, Mehmet Ali BAŞ, Ates DUMAN

Pages : 658-665

Doi:10.54005/geneltip.1116922

View : 15 | Download : 7

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :Aim: Hypothermia is a rare complication of antipsychotic drugs but serious outcomes including death may result. In this study, we aimed to investigate body temperature alterations in acute phase of chlorpromazine treatment, the relationship of inflammatory indicators and risk factors for hypothermic effect in intensive care unit insert ignore into journalissuearticles values(ICU); patients. Materials and methods: 63 intensive care patients who needed sedative treatment due to agitation were divided into two groups as Group 1 insert ignore into journalissuearticles values(n = 30); with temperatures ≤ 38°C, and Group 2 insert ignore into journalissuearticles values(n = 33); with temperatures > 38°C according to baseline body temperatures. Also, recurrent measurements for 12 hours were made at specific intervals following 25 mg intravenous chlorpromazine. Results: In Group 1, decrease in body temperatures was significant from 4th to 12th hours insert ignore into journalissuearticles values(p < 0.01);, while in Group 2, significant decreases in body temperatures at all measurement hours were observed insert ignore into journalissuearticles values(p < 0.01);. Temperature changes insert ignore into journalissuearticles values(delta temperature); observed at specific measurement intervals were significantly higher in Group 2 compared to Group 1. That difference was statistically significant at all intervals except for ΔTemperature B-6 insert ignore into journalissuearticles values(p < 0.05);. The odds of hypothermic effects by chlorpromazine were 16%, 46%, 3%, and 18% for Acute Physiology and Chronic Health Evaluation II, procalcitonin, C-reactive protein, and white blood cells, respectively. Conclusion: Chlorpromazine treatment applied for agitation in ICU patients was associated with acute hypothermic effect. Severity of disease and comorbidities might increase risk of hypothermia, and inflammatory biomarkers might be predictors of adverse drug reaction.
Keywords : adverse drug reaction, body temperature changes, chlorpromazine, intensive care unit, psychomotor agitation