Does Gadopentetate Dimeglumine Induce Gadolinium Accumulation in the Brains of Children?

Authors : Ayşegül GÖRMEZ, Osman Melih TOPCUOĞLU

Pages : 123-127

Doi:10.54005/geneltip.1193667

View : 13 | Download : 7

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Aim: To determine T1-weighted insert ignore into journalissuearticles values(T1W); signal intensity insert ignore into journalissuearticles values(SI); differences in the dentate nucleus insert ignore into journalissuearticles values(DN); and globus pallidus insert ignore into journalissuearticles values(GP); following contrast enhanced magnetic resonance imaging insert ignore into journalissuearticles values(MRI); with multiple gadopentetate dimeglumine administrations in a group of pediatric patients. Methods and materials: This retrospective study included children with at least two enhanced brain MRIs. All patients received gadopentetate dimeglumine intravenously insert ignore into journalissuearticles values(0.1 mmol/kg);. SI measurements were done by drawing five region of interests insert ignore into journalissuearticles values(ROI); on dentate nuclei insert ignore into journalissuearticles values(DN); and globus pallidi insert ignore into journalissuearticles values(GP); bilaterally and cerebro-spinal fluid insert ignore into journalissuearticles values(CSF); in unenhanced T1W images. Student t-test was used for comparison of SI. Pearson correlation was calculated for the correlation between the SI and the number of gadolinium administrations. Results: A total of 31 children insert ignore into journalissuearticles values(age range: 3-17 years; mean 10.6±4.3 years); were included. There was no significant difference between the first and the third MRI scans by means of the T1 SI ratios: right and left DN/CSF, right and left GP/CSF insert ignore into journalissuearticles values(P =0.543, P =0.599, P =0.803, P =0.730, respectively);. 18 patients received more than two gadopentetate dimeglumine, the mean number of administrations was 5±3. A significant difference was detected between first and last MRI scans; right and left DN/CSF, right and left GP/CSF insert ignore into journalissuearticles values(P=0.0004, P=0.0008, P=0.0001, P=0.014 respectively);. Correlation between the number of gadopentetate dimeglumine administrations and the SI for right and left DN/CSF, right and left GP/CSF insert ignore into journalissuearticles values(r=0.13, r=0.13, r=0.09 and r=0.12, respectively); was poor. Conclusion: There was no significant T1 SI increase for children with at least two gadopentetate dimeglumine administrations but after multiple administrations, significant T1 SI increase was found in this series.
Keywords : kontrast madde, beyin MRG, linear, gadolinium birikimi