The Effects of Natural and Artifical Sweeteners on Glucose Intolerance, Liver Enzymes and Oxidative Stress in Rats with Type 2 Diabetes

Authors : Merve Pehlivan, Eda Köksal

Pages : 1518-1526

Doi:10.37989/gumussagbil.1560223

View : 36 | Download : 28

Publication Date : 2024-12-25

Article Type : Research Paper

Abstract :The impacts of artificial and sweeteners on liver enzymes, glucose intolerance, and oxidative stress were investigated in the present research. Sixty adult male Wistar rats were indiscriminately distributed to two groups, involving 30 in each. The first group was made diabetic with streptozocin, and the second group was called the healthy control group. Then, these groups were divided into 3 different groups again and these groups were given 250 mg/kg daily of Aspartame and Stevia and followed for 5 weeks to compare their effects. A comparison between the groups indicated that the diabetic stevia group had lower levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose, and HbA1c values than the diabetic aspartame group (p<0.001). The diabetic aspartame group had higher levels of tumor necrosis factor-alpha (TNF-alpha) value than the stevia control (p<0.001). The aspartame control group had higher levels of interleukin 1 (IL-1) than the healthy control group (p<0.001). The interleukin-6 (IL-6) value of the diabetic aspartame group was found to be noticeably higher than the healthy control group (p<0.001). The total antioxidant capacity (TAS) of the diabetic, healthy control and stevia groups was found to be considerably higher than the diabetic and control aspartame groups (p<0.001). The total oxidant capacity (TOS) of the diabetic and control aspartame groups was notably high when compared to the value of the control stevia group (p<0.001). As a result, aspartame significantly increases AST, HbA1c, blood glucose, TNF-alpha, ALT, TOS, IL-1, and IL-6 figures compared to stevia but radically decreases TAS values.
Keywords : Tatlandırıcılar, Glukoz İntoleransı, Karaciğer Enzimleri, Oksidatif Stres